Reid has since starred in Filipino movies such as Talk Back and You're Dead (2014), Para sa Hopeless Romantic (2015), This Time (2016) and Never Not Love You (2018).

Reid has stated before that he found it difficult to adjust to his new life in the Philippines, especially due to the different academic and social skills required, as well as language difficulties.

After the complications, Reid was able to return to the Big Brother house but needed to rest frequently as well as constantly wearing an oxygen tube for one week.

One 8 June 2010 (Day 60), Reid was notified by the producers of Big Brother that he was no longer required to use the oxygen tube except while sleeping.

On 24 July 2011, Reid, together with Pinoy Big Brother housemate Bret Jackson, launched their first digital EP entitled We Are Whatever on ASAP Rocks.

[11][12] Reid and Jackson recorded four original songs,including "Can't Dance" featuring their co-housemates Ann Li and Fretzie Bercede.

[30] On 2 June 2014, it was confirmed that he and Lustre would star in another film titled Talk Back and You're Dead together with Yassi Pressman and Joseph Marco.

[33] On 22 October 2014, it was announced that he and Lustre will do another movie entitled Para sa Hopeless Romantic together with Julia Barretto, Iñigo Pascual, AJ Muhlach and Shy Carlos.

[38][39] As part of the contract, Reid and his onscreen partner Nadine Lustre starred in their first TV series together as a loveteam entitled Wansapanataym Presents: My App #Boyfie which was also based on Wattpad story.

[46] On 10 January, Reid's new music video for the song "Huwag Ka Nang Humirit", composed by Thyro Alfaro and Yumi Lacsamana, premiered on Viva's YouTube channel.

[49] It was also used as the theme song for his then upcoming movies with Lustre such as Diary Ng Panget, Talk Back You're Dead, and Para sa Hopeless Romantic.

[51] On 20 February 2016, Reid and his on-screen partner, Nadine Lustre, had their first major concert titled "JaDine In Love" at the Smart Araneta Coliseum.

[53] In June 2016, it was announced that Reid and Lustre will be making their small screen comeback through the series, Till I Met You, with JC Santos, Angel Aquino, Carmina Villarroel, and Zoren Legaspi.

Reid was also set to star in the new Pedro Penduko adaptation of Viva Films, which was based on the re-imagined version written by Regene Estolatan under Epik Studios.

[61] Transitioning to an independent artist, Reid said he would take a break from acting to focus on his music career and working on Careless.

[62] In 2020, Reid was slated to perform at the Overpass Music Festival which was to be held at Oak Canyon Park in Orange County, California.

[64] On May 30, Reid participated in Our Identity: ProjectBlue Marble, an online musical event which also served as a global fundraising effort in the fight against COVID-19 and to combat xenophobia affecting Asian communities.

[70] On October 6, 2024, James Reid made a homecoming comeback as a Kapamilya at ASAP, appearing on the show first time after 6 years.

"[72] He has also mentioned being influenced by Thyro Alfaro, Yumi Lacsamana, who wrote most of Reid's tracks from his LP and EP releases under Viva Records.

[79] Reid is currently residing in Los Angeles, California with artists he is handling from his Careless music label and management agency, including Liza Soberano.