James Ruffin (born February 6, 1987) is a former American football defensive end.

He played college football at University of Northern Iowa.

[1] Ruffin was signed by the Tampa Bay Buccaneers as an undrafted free agent in 2010.

[4] Ruffin's play in 2014 earned him the AFL's Defensive Lineman of the Year Award.

This biographical article relating to an American football defensive lineman born in the 1980s is a stub.