James Joseph Wyche (born April 19, 1982) is an American former professional football defensive end.
Wyche attended Roosevelt High School, and was All-state and Newsday All-Long Island selection.
He finished career with 162 tackles, 34 sacks, two blocked punts and two interceptions as a two-year starter.
Wyche was selected by the Jacksonville Jaguars in the seventh round with the 213th pick of the 2006 NFL draft.
In 2008, he missed the entire season with a knee injury suffered in the preseason and was placed on injured reserve on August 9, 2008.