He aided the papal auditor, Bernardo da Bosco, in putting an end to the teaching of impious doctrines at Bergamo.
Brescia also took a prominent part in the controversy between the Dominicans and the Minorites with regard to the Precious Blood.
During Easter Week, 1462, St. James of the Marches, a celebrated Minorite preacher, maintained in a sermon at Brescia that the Blood separated from the Body of Christ during His Passion was thereby separated from His Divinity, and consequently was not entitled to adoration during the time that Christ remained in the sepulchre.
Shortly before, in a papal bull written at Tivoli, Pope Pius II had declared that it was not contrary to Christian faith to hold that Christ did not reassume a part of the blood he shed in his passion.
A full presentation of the Dominican side of this controversy is preserved in an unpublished treatise written by James of Brescia and his two colleagues.