Jamestown (Irish: Cill Srianáin)[1] is a village on the banks of the River Shannon in the south of County Leitrim, Ireland.

It was named after King James VI & I. Jamestown was built as a walled town during the Plantation of Leitrim for early to mid-seventeenth-century English settlers alongside the earlier settlement of Cill Srianáin, which had included an abbey.

Navigation for cruisers is not possible downstream of Jamestown, boats being required to use the Jamestown Canal and Albert Lock, which links to the Shannon south of Drumsna The Plantation settlement was created by Royal Charter from King James VI & I in 1621 and was founded in 1622 as a plantation town carrying into action the decision of 1620 to plant County Leitrim with loyal English settlers.

In 1713, an elderly Father Connor Reynolds "of Jamestown in the county of Leitrim" exiled in Spain since 1681, was captured hiding in a trunk on a fishing boat arriving at Dungarvan port and imprisoned at Waterford gaol.

[3] The Borough with a very restricted franchise returned two members to the Irish Parliament until the Act of Union with Britain in 1801.

Among its parliamentary representatives were Sir Charles Coote (1634–1660), John Fitzgibbon (1776; he was later elevated to the peerage in 1789, eventually becoming Earl of Clare in 1795), and Richard Martin, "Humanity Dick".