The road runs west into County Westmeath and bypasses Rochfordbridge, with the N52 joining the M6 east of Tyrrellspass.

The route bypasses Fardrum (where the N62 begins, leaving the N6 to the south) heading west towards Athlone.

The route follows a dual carriageway bypass of Athlone around the northern side of the town, crossing the River Shannon into County Roscommon.

This dual carriageway bypass brings the route into Galway itself, where it meets the N83 along Bóthar na dTreabh.

R446 ‒ Milltownpass R389 – Kilbeggan N55 ‒ Cavan, Longford R355 – Portumna R347 ‒ Craughwell M18 ‒ Limerick Motorway terminates at roundabout.