In the 1994 episode of Seinfeld, "The Stall", she appeared as one of Jerry's girlfriends, who works as a phone sex operator and can't "spare a square" of toilet paper for Elaine in the restroom.

Also in 1994, she played Sarah in the TV movie This Can't Be Love, starring: Katharine Hepburn, Anthony Quinn and Jason Bateman.

[9] In 2000, Gertz took up a recurring role on the Fox hit Ally McBeal as Kimmy Bishop, John Cage's love interest.

In 2011, she earned a producer's credit on the Academy Award-nominated film A Better Life, which was put in limited release throughout the month of June and early July before arriving on DVD in October.

From 2012 to 2014, Gertz starred in the ABC sitcom The Neighbors, in which she played the mother of a human family that moves into a neighborhood populated by residents from another planet.

[10][11][12] Gertz and her husband are members of the investment group led by Mark Attanasio which purchased the Milwaukee Brewers of Major League Baseball.

Gertz-Ressler High Academy, a member of Alliance College-Ready Public Schools, is named for Gertz and her husband.