Dukes was an offensive guard at Florida State and became the fifth player in FSU history to earn consensus All-America honors when he was named to virtually every team as a senior in 1985.
Following his illustrious career with Florida State, Dukes signed with the Atlanta Falcons as a free agent in 1986.
As of 2010, Dukes spearheaded a grassroots, weight-loss program called the "Billion Pound Blitz Initiative".
[15][16][17][18] Duke is Senior VP of Community Relations & Strategic Partnerships for Hydro One a healthy, nutritional, vitamin infused beverage.
January 29, 2015, Jamie Dukes seeks fellow ex-NFLers for study to treat depression in the foyer of Georgia State Capitol.
Dukes is working with anesthesiologist Jarrod Huey who is involved with Atlanta-based DripFusion Institute in collaboration with several organizations including Florida State University College of Medicine[20][21] Dukes wrote a book called "Frenemals", which talks about Family, Friends, and the Friends inside our head.
[23] Dukes and his wife kicked off the 2011 Runway Red Celebrity Kids Fashion Show raising funding for children infected by or affected with HIV/AIDS.