Jamyang Shakya Gyaltsen (Tibetan: འཇམ་དབྱངས་ཤ་ཀྱ་རྒྱལ་མཚན, Wylie: aJam dbyangs sha kya rgyal mts'an, 1340–1373) was a ruler of Central Tibet in 1364–1373.
At the time of Jamyang Shakya Gyaltsen's accession, the Mongol Yuan dynasty was at its last throes, and had little or no opportunity to intervene in the affairs of Tibet like before.
In 1365, however, the new regent received the title Gushri and the investiture of the Nêdong district, the original fief of the Phagmogrupa line, from the emperor Toghon Temür.
The Mingshi or dynastic annals say: "In the beginning of the fifth year Hongwu [1372] the [commander of the] garrison of Hezhou said that in the country of Pamuzhuba [Phagmodrupa] in Ü and Tsang there was a monk who was called Zhangyang Shajia Jiancang [Jamyang Shakya Gyaltsen], to whom in the Yuan's times, had been given the title of Guanding Guoshi, and to whom the barbarians had been entrusted.
Now Shangzhu Jiancang [Changchub Gyaltsen, another person than the regent's predecessor], the chief of Dogan [Do Kham], fought against Guan Wuer.
The Emperor accepted this advice, and again appointed that monk Guanding Guoshi, and sent envoys to him to give him the jade seal and coloured silk.