The church ran an active Neighborhood House that promoted music, theater, and culture and operated a homeless outreach program.

In 2019, the Session of Jan Hus Presbyterian sold the 23,000-square-foot (2,100 m2) church building located at 351 East 74th Street, New York City, New York, in Manhattan's Upper East Side to purchase a more modern facility to meet the growing needs of the congregation and their large community outreach missions.

[6][7] The church was founded in 1877 when Gustav Alexy, a Hungarian missionary, wanted to work among the Czech community.

[8][9] The building was designed by R.H. Robertson and built in 1888, and bears the inscription "Truth Prevails", a famous Jan Hus saying.

The church sits down the block from the Byzantine Moderne-style Greek Orthodox Archdiocesan Cathedral of the Holy Trinity.

[10] When Pastor Alexy died in 1880, the newly official Presbyterian Church asked 21-year-old Vincent Pisek to take over as leader.

Through the efforts Vincenc Pisek of Malesov, the successor of Gustav Alexy of Roznov, the new modern Czech Brethren Presbyterian House was built in 1888.

[22] Among its many community efforts Jan Hus Church organized a homeless outreach program called HOAP.

Located on the easternmost portion of our building, the Neighborhood House was to be a cultural and social center for the Bohemian people, a place for art and music, job training, a dental clinic, clubs, athletics, language classes and more.

[43] Second Chance for Star-Studded Theater With a community-minded focus, drama in the basement of an East Side church, By Deirdre Donovan, Our Town, April 28, 2010