She had earlier signed Vinnaithaandi Varuvaayaa to play the second lead actress, but her role was later shot featuring Samantha Ruth Prabhu.

[4] The comedy-drama film featured Janani in the role of an innocent police constable opposite Vishal, and her performance won her positive reviews from critics.

[10] A critic from Sify wrote, "Janani Iyer looks beautiful and it is a relief to watch a Tamil girl speaking in her own voice.

[12] In 2014, she appeared alongside Ashok Selvan in the crime thriller Thegidi, which won positive reviews and became a surprise success at the box office.

She also featured opposite actor Asif Ali in successive ventures, Mosayile Kuthira Meenukal (2014) and Ithu Thaanda Police (2016).