[3] Doolittle served for many years as the principal of Iran Bethel School for Girls, which was the immediate forerunner of Damavand College.
[5][6] She went to Tehran in order to respond to an urgent appeal to replace the biology teacher at the Iran Bethel School for Girls (also known as the American Presbyterian School for Girls in Tehran).
In 1939, as Reza Shah was favorably inclined towards Germany and was convinced that Germans would be victors in the World War II, shortly before the outbreak of war he ordered for the closure of many educational works.
Hoping to avoid this, Doolittle asked an Iranian doctor to take the clinic under his jurisdiction, thus insuring its continuance.
In her old age she lived in Cortland, New York in an apartment furnished by her classmates from Wells College.