She also appeared as Linda in Equal Justice (1990–1991), Judge Trudy Kessler in Raising the Bar (2008–2009), Ann in Falling in Love (1984), Emily in The Heavenly Kid (1985), and Gayle in 6 Balloons (2018).

[10] TV Guide dubbed her role in the series as a "true breakout; a female Homer Simpson", and critics hailed her for her comic talents.

[13] On July 22, 2011, it was confirmed that Kaczmarek would make a vocal appearance as Red Jessica in the television series Jake and the Never Land Pirates during its second season early 2012.

[14] Kaczmarek was the narrator in the 2011 Wisconsin Educational Communications Board and PBS production of Wisconsin's Nazi Resistance: The Mildred Fish-Harnack Story, a documentary about the life of fellow Milwaukee native Mildred Fish-Harnack who in 1943 was the only American woman to ever be personally sentenced to death by order of Adolf Hitler for her role in the German Nazi Resistance Movement.

In 2013, Kaczmarek guest starred on NBC's long-running legal drama, Law & Order: Special Victims Unit, as Suffolk County D.A.

[16] Kaczmarek and former Malcolm in the Middle co-star Bryan Cranston reprised their roles as Lois and Hal respectively in an "alternate ending" featurette on the Breaking Bad DVD/Blu-ray box set that was released on November 26, 2013.