[3][4] At age 35, she was one of many young ANC youth league members who were sworn into the National Assembly after the election.
[6] In a committee meeting in August 2020, she commended Thidziambi Tshivhase Phendla, who was dismissed from the University of Venda for allegedly meddling in the awarding of a tender to a cleaning company, "for breaking the silence" by reporting former Venda University vice-chancellor Peter Mbati for sexual harassment.
[7] During a question and answer session in the National Assembly on 5 March 2021, she made the claim that black university heads were not carrying their weight, compared with those of other race groups at institutions of higher learning.
Her claim was quickly denounced by the Minister of Higher Education, Science and Technology, Dr. Blade Nzimande, as well as the vice-chancellor of the University of Fort Hare, Professor Sakhela Buhlungu.
[10] Following the 2024 general election, Mananiso was sworn into the National Council of Provinces as a Permanent Delegate from Gauteng.