Velez-Mitchell previously worked for HLN's Nancy Grace as producer and fill-in host, and continued to function in the fill-in capacity until her departure in late 2014.

According to the show's website, the program "stands up for the less fortunate and demands justice for all.

In 2010, Issues with Jane Velez-Mitchell was nominated for a GLAAD Media Award for "Outstanding TV Journalism Segment" for the segment "Gay Teen Mutilated" during the 21st GLAAD Media Awards.

On October 14, 2014, the program was unexpectedly canceled by CNN as part of continuing budget cuts across the entire organization under the "Turner 2020" reorganization initiative, with the day before's program being the last to air.

As with nearly all of the program removals over the last year on HLN, Forensic Files repeats are expected to fill the timeslot.