She was awarded the Kavli Prize (shared with David C. Jewitt and Michael Brown) for 2012 "for discovering and characterizing the Kuiper Belt and its largest members, work that led to a major advance in the understanding of the history of our planetary system".

[5] As a graduate student at the University of California at Berkeley[6] and the Massachusetts Institute of Technology, she looked at links between asteroids and comets for her main PhD project.

In 1992, after five years of observation, they found the first known Kuiper Belt object other than Pluto and its largest moon Charon, using the University of Hawaii's 2.2 meter telescope on Mauna Kea.

[8] Following her time in Europe, Luu returned to the United States and worked on instrumentation as a Senior Scientist at Lincoln Laboratory at MIT, focusing on defense-industry projects, specifically lidar systems.

[14] In 2012, she won (along with David C. Jewitt of the University of California at Los Angeles) the Shaw Prize "for their discovery and characterization of trans-Neptunian bodies, an archeological treasure dating back to the formation of the solar system and the long-sought source of short period comets"[15] and the Kavli Prize (shared with Jewitt and Michael E. Brown) "for discovering and characterizing the Kuiper Belt and its largest members, work that led to a major advance in the understanding of the history of our planetary system".