[5] As of 2001,[update] The Poky Little Puppy was the single all-time best-selling hardcover children's book in the U.S., having sold nearly 15 million copies.
[6] While the book has outsold many other famous books such as Dr. Seuss' Green Eggs and Ham, Lowrey herself (who also wrote stories about children in her home state of Texas) remained in relative obscurity until her death.
The Poky Little Puppy remains her best known, selling over 15 million copies worldwide.
Another well-known work of hers was Margaret, a historical fiction young adult novel, which was published in 1950.
It was adapted into Walt Disney Presents: Annette, a TV serial that aired on The Mickey Mouse Club in 1958.