He got his big break in 2008 at COSAFA U-20 Challenge Cup in South Africa when he was called to replace another referee who had failed a fitness test.

[4] On 7 January 2023 he officiated his last career match between Napsa Stars and Red Arrows.

[4] He was selected to officiate at the 2018 FIFA World Cup in Russia, and made his debut in the Belgium vs Panama Group G game on 18 June.

The match also saw him going into the record books as he became the first Zambian referee to officiate a game at the FIFA World Cup finals.

A forensic report stated that Sikazwe suffered heat stroke, which contributed to his mishandling of the match.