National Route 10 (国道10号, Kokudō Jū-gō) is a Japanese highway on the island of Kyushu.

It originates at the intersection with Route 2 in Kitakyushu, Furoka and passes through the prefectural capitals of Ōita and Miyazaki, terminating at the intersection with Route 3 in Kagoshima.

Route 10 follows the eastern coast along the Inland Sea and the Hyūga Sea.

For much of its length, it parallels the JR Kyushu Nippō Main Line.

Route 10 measures 454.8 km in length.