National Route 108 is a national highway of Japan connecting Ishinomaki and Yurihonjō, Akita in Japan, with a total length of 186.9 kilometers (116.1 mi).

Route 108 was originally designated on 18 May 1953 as a route from Ishinomaki to Shinbori (now Sakata) via Furukawa (now Osaki).

On 1 April 1963, the route was shortened to Furukawa and rerouted to Yokote, replacing Route 109; the original route to Sakata was incorporated into Route 47.

On 1 April 1970, the northern terminus was moved to Honjo (now Yurihonjō).

This article relating to the roads and highways in Japan is a stub.