National Route 141 is a national highway of Japan connecting Nirasaki, Yamanashi and Ueda, Nagano in Japan, with a total length of 104.9 km (65.2 mi).

When designated on 18 May 1953, Route 141 originally ran from Shimizu to Ueda.

The section from Shimizu to Nirasaki was redesignated as Route 52 on 1 April 1963, shortening Route 141 to its current route.

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