[3] Genao began his acting career in 2015, when he appeared in the comedy film Ladrones.
In 2016, Genao appeared in a recurring role–as Napoleon in the Netflix Original series The Get Down.
Genao was cast to play the main role in the teen comedy-drama series On My Block alongside Sierra Capri, Brett Gray and Diego Tinoco, which was released on Netflix on March 16, 2018 and final season which premiered on October 4, 2021.
[4][5] In 2022, Genao appeared in a recurring role as Devon in the comedy miniseries Boo, Bitch.
In 2023, Genao was cast in the war action thriller film Ambush opposite Jonathan Rhys Meyers, Connor Paolo and Aaron Eckhart, which was released on February 24, 2023.