One of his most well-known ad campaigns are the three TV commercials for Gap he did with director Pedro Romhanyi in 1999: "Everybody in Cords", "Everybody in Leather" and "Everybody in Vests".
Though modeling paid the bills and allowed Jason the opportunity to travel extensively, he admits that becoming an actor was never far from his thoughts.
Thompson's most popular role to date is that of Dr. Patrick Drake on the ABC soap opera General Hospital.
Since playboy Patrick Drake's first appearance on the show, he has flirted with various women (many who work at the hospital call him Dr. Hottie in reference to his good looks and as a tribute to fellow ABC hot doc Grey's Anatomy character Dr. McDreamy), saved many lives, and mended a contentious relationship with his father, Dr. Noah Drake (played by returning castmember Rick Springfield).
As part of ABC's Fan February promotions in 2007, Thompson switched places with a first-grade teacher for a day and taught her class in Irving, Texas.