In August 2016, it was announced that Christopher would be joining the cast of the NBC soap opera Days of Our Lives[1] as the son of long-time villains Stefano DiMera and Vivian Alamain.

[8] In April 1996, Christopher was cast in the role of Nikolas Cassadine for the serial; he signed a three-year deal and filmed his first scenes in late June 1996.

[10] Following his daytime departure, Christopher made guest appearances on primetime shows including Charmed, Angel, Felicity, and CSI: Crime Scene Investigation.

[11] In March 2011, Soap Opera Digest reported on their social media accounts that Christopher had been let go from the serial, because of his casting on ABC Family's The Lying Game, produced by former General Hospital head writer Charles Pratt Jr.[12][13] Christopher verified the reports of his firing to ABC Soaps In Depth; he explained that he had been released from his deal on Friday March 18, 2011, and the character of Nikolas was to be written out.

[citation needed] In March 2013, Christopher returned in a recurring capacity at General Hospital, while continuing to appear on The Lying Game.

[33] In November 2019 while Christopher was going through alcohol withdrawal, he experienced delirium tremens, leading to a fall during which he hit his head on the edge of a bathtub and sustained a traumatic brain injury.

[35] After recovering from his head injury and ending a medical guardianship under his sister in September 2021, Christopher moved to Hollywood from Ohio to try to find work as an actor where he was homeless for the first six months.

[32][36] Before his death, he was close friends with General Hospital co-star Maurice Benard who is also diagnosed with bipolar disorder and gave support to Christopher.

[37][38] On November 11, 2019, Christopher was arrested and charged with public intoxication in Martinsville, Morgan County, Indiana after falling asleep in the back of an Uber car.

[39] From January 2020 to September 2021, Christopher was placed under the medical guardianship of his sister Susan Asmo Baker following a nearly fatal head injury.