Often cast in creature roles, he portrayed Tristana Medeiros in the REC franchise (2007–2009), the title character in Mama (2013), Set in The Mummy (2017), Slender Man in the 2018 film of the same name, and Dracula in The Last Voyage of the Demeter (2023).

His appearances in horror films also include Crimson Peak (2015), The Conjuring 2 (2016), It (2017) and its 2019 sequel, Insidious: The Last Key (2018), and Scary Stories to Tell in the Dark (2019).

[3] Botet's unique physique, coupled with a personal interest in performing and fantasy, eventually led to his being cast in Brian Yuzna's Beneath Still Waters (2005).

[5] He has also appeared on television, including as a member of an alien species known as the Ba'ul in a 2019 episode of Star Trek: Discovery.

[7] On 7 October 2019, Botet, along with actress Maribel Verdú, received the Màquina del Temps (English: Time Machine) award at the 2019 Sitges Film Festival.