The band originated in 2005 on the German RTL II television reality show Big in America and debuted in June of the same year on Lou Pearlman’s Transcontinental label.

US5 enjoyed success, gaining their first Gold Record in America from their first single called "Maria" released in 2005.

[1] The same song went straight in at number 1 in Germany and became a huge summer hit in several other European countries.

US5 released their single "The Boys Are Back" from the successful film High School Musical 3.

The last line-up of US5 was Richie Stringini, Izzy Gallegos, Cayce Clayton, Jayson Pena all from the United States, and Jay Khan from England.