[1][2][3] Jayanthi comes from a lineage of musicians who have been practising Carnatic music for six generations and started playing the Saraswati Veena at the age of 3.

Her mother, Lalgudi Rajalakshmi, was her first teacher and she later underwent intense training from her maternal aunt, Padmavathy Ananthagopalan.

A researcher, Jayanthi holds a doctorate for her work on "styles and playing techniques of the Saraswati veena" and conducts workshops and lecture demonstrations around the world.

She founded the Indian National Orchestra,[4] where a group of artists from Carnatic and Hindustani genres representing the rich musical and cultural heritage of India come together under one banner to showcase Indian classical music.

Jayanthi composed and released the album "Mysterious Duality,"[5] The artist has played 7 different Veena tracks.