Jean-Marc Samuel Isaac Mousson (17 February 1776 – 21 June 1861) was a Swiss politician and civil servant.

the descendant of Huguenot refugees from Le Mas-d'Azil in the French County of Foix who took up refuge on the Vaud side of Lake Geneva, in Morges following the revocation of the Edict of Nantes by Louis XIV.

[clarification needed] The Directorate of the Helvetic Republic appointed Mousson in June 1798 to the post of Secretary-General.

From September 1833 to January 1834, he was part of the arbitral tribunal that legally regulated the separation of the canton of Basel.

He spent the last 20 years of his life in Zürich, on "Zur Schonau", the property of his son Heinrich, overlooking the city.