It runs from Décarie Boulevard in the west through Anjou in the east to Galeries d'Anjou.

In the Town of Mount Royal, it is called Dresden Avenue.

Between Viau Boulevard and Langelier Boulevard in the Montreal borough of Saint-Léonard, Jean Talon Street passes through the heart of Montreal's Italian community and is nicknamed Via Italia.

It is home to many Italian Canadian businesses and runs through the largest Italian-Canadian community in Montreal.

There are 260,345 people of Italian ancestry living within the Greater Montreal Area.