Jean Le Clerc applied himself to the study of philosophy under Jean-Robert Chouet (1642–1731) the Cartesian, and attended the theological lectures of Philippe Mestrezat, François Turrettini and Louis Tronchin (de) (1629–1705).
Due to political instability, he moved to Amsterdam, where he was introduced to John Locke and to Philipp van Limborch, professor at the Remonstrant college.
He later included Locke in the journals he edited; and the acquaintance with Limborch soon ripened into a close friendship, which strengthened his preference for the Remonstrant theology, already favorably known to him by the writings of his grand-uncle, Stephan Curcellaeus (d. 1645) and by those of Simon Episcopius.
[1] A last attempt to live at Geneva, made at the request of relatives there, satisfied him that the theological atmosphere was uncongenial, and in 1684 he finally settled in Amsterdam, first as a moderately successful preacher, until ecclesiastical jealousy reportedly shut him out from that career, and afterwards as professor of philosophy, belles-lettres and Hebrew in the Remonstrant seminary.
They deal with the doctrine of the Trinity, the Hypostatic union of the two natures in Jesus Christ, original sin, and other topics, in a manner unorthodox for the period.
[3][4] In turn, Charles Gildon published a partial and unattributed translation of Le Clerc's Logica as the treatise "Logic; or, The Art of Reasoning" in the second (1712) and subsequent editions of John Brightland's Grammar of the English Tongue.
[7] In particular, the article on définition (1754) in the Encyclopédie can be traced through this chain of writers, editors, translators, and compilers to the Port-Royal Logique through the Logica of Jean Le Clerc.
Le Clerc's commentary challenged traditional views and argued the case for inquiry into the origin and meaning of the biblical books, It was hotly attacked on all sides.