She began her professional life in accounting and auditing, working in this field from 1949 to 1963 in Sydney, Australia, and in London, England.

[3] This marked the beginning of her long-career working for organizations connected to the Methodist Church, and later, the wider ecumenical movement.

At this global gathering of ecumenical leaders, she was elected as Vice-Moderator of the Central Committee of the WCC, a post she held from 1975 to 1983.

[3][2][7] Skuse was a member of the group Christian Women Concerned, which was the first explicitly religious feminist organisation in Australia.

[12] An interview with Skuse, conducted by Australian historian Hazel de Berg in 1977, is also held at the National Library of Australia.