[citation needed] On radio, she was heard on such programs as The Halls of Ivy (1950–52) and on Father Knows Best during the early 1950s, where she portrayed Margaret Anderson; the role was played on television by Jane Wyatt.

Her husband, Carroll G. O'Meara, was a graduate of Stanford University who worked as a copywriter at KHJ radio in the mid-1930s and later became an advertising executive.

[5] Vander Pyl made numerous TV appearances as an actress in programs such as Leave It to Beaver, The Donna Reed Show, Father Knows Best, The Beverly Hillbillies, That Girl, and Petticoat Junction.

Vander Pyl also had a cameo appearance in the 1994 live-action film version of The Flintstones as Mrs. Feldspar, an elderly woman in a conga line right behind Dino.

She told an interviewer in 1995 that she received $250 per episode for making The Flintstones, and in 1966, when the series ended, she rushed to accept $15,000 in lieu of residual payments from syndication.

In 1961–62, Vander Pyl played Nurse Larue, Charlie the baby, Goldie, Lola Glamour, and additional voices on multiple episodes of Top Cat and in 1962, she did another memorable role, as Rosie, the Jetsons' robotic maid, and 23 years later in 1985 she reprised the character on the returning series.

She went on to voice Mrs. Finkerton on Inch High, Private Eye, and several female characters on Hong Kong Phooey, The Tom and Jerry Show, and Captain Caveman and the Teen Angels.

[1] On April 10, 1999, Vander Pyl, the last surviving original cast member of The Flintstones, died of lung cancer at her home in Dana Point, California, at the age of 79.