[1] Bosschère was born in Uccle, the son of Charles de Bosschere and Nancy Marie Hélène Van der Stock.

The style of these illustrations, as well as his later work, was a version of Art Nouveau heavily influenced by the drawings of Aubrey Beardsley.

He was also influenced by the Roman Catholic spiritual works of French poet and dramatist Paul Claudel, whom he saw lecture in 1909.

That same year, he began a lifelong friendship with the Antwerp Symbolist poet Max Elskamp (of whom in 1914, he published a critical study), and in 1911, of the French writer Andre Suares.

In 1915, after the outbreak of World War I, he fled from Belgium and went to London where he met writers such as John Gould Fletcher, Aldous Huxley and D. H. Lawrence, and Imagist poets such as Ezra Pound, T. S. Eliot and Richard Aldington.

They also stayed regularly Solaia near Siena in Italy, where De Bosschere worked on his many novels and poetry collections.

He wrote several novels that he regarded as failures and found little illustration work due to the poor economic climate.