It was named in 1914 in honour of Jeanne Mance, the founder of the Hôtel-Dieu de Montréal, which is also located along this street.

Jeanne Mance Street spans nearly the entire island of Montreal, but in several discontinuous portions.

It then continues in several discontinuous stretches along the same axis and ends slightly north of Gouin Boulevard.

Complexe Desjardins, the Musée d'art contemporain de Montréal, Montreal, arts interculturels, Place-des-Arts station and UQAM's President Kennedy building are all located along this street.

[1] Between De Maisonneuve Boulevard and Sherbrooke Street, on the west side, a series of Victorian-style houses with culturally significant façades were saved from demolition: