Kagame is the founder and chairman of Imbuto Foundation,[2] a non-profit organization whose mission is to support the development of a healthy, educated and prosperous society.

[3] She has since become devoted to uplifting the lives of vulnerable population in Rwanda, particularly those of widows, orphans and impoverished families.

[3] Over the years, PACFA grew to include projects other than those in the HIV/AIDS domain and in 2007 the Imbuto Foundation - which means “seed” in Kinyarwanda - was established.

The First Lady is also a patron of the Rotary Club Virunga, based in Kigali, which established the first public library in Rwanda in 2012.

[3] In 2010, Kagame received an Honorary Doctor of Laws from Oklahoma Christian University for her contribution to the worldwide fight against HIV/AIDS and poverty.