She is best known for her role in the 1972 comedy film The Heartbreak Kid, for which she received Academy Award and Golden Globe nominations for Best Supporting Actress.

She later played the leading role in Sheila Levine Is Dead and Living in New York (1975), and has acted in films such as Margaret (2011), Inherent Vice (2014), Café Society (2016), The Fabelmans (2022), and You Hurt My Feelings (2023).

[2] Berlin made her screen debut appearing in a supporting role in the made-for-television film In Name Only starring Eve Arden.

She acted on the New York stage and began appearing in a number of films, including Getting Straight (1970), The Strawberry Statement (1970), Move (1970), The Baby Maker (1970), Portnoy's Complaint (1971), and Bone (1972).

[5] In 1972, Berlin's performance in the comedy film The Heartbreak Kid, directed by her mother and with a screenplay by Neil Simon, garnered her Golden Globe[6] and Academy Award nominations for Best Supporting Actress.

She later appeared in Paul Thomas Anderson's crime film Inherent Vice (2014) and Woody Allen's romantic comedy-drama Café Society (2016).

[13][14] She was named a contender for a Primetime Emmy Award for Outstanding Supporting Actress in a Limited or Anthology Series or Movie nomination, which did not come to fruition.