He made his entertainment industry debut in 1992 as a singer and gained worldwide popularity with the variety show Running Man (2010–present).

[3][4] In 1992, Jee Seok-jin debuted as a singer, releasing his first album "I Know",[5] but gained popularity as an MC and comedian in the entertainment industry.

[6] Jee is most well known as a cast member in the variety show Running Man together with Yoo Jae-suk, Kim Jong-kook, Haha, Song Ji-hyo, Lee Kwang-soo, Jeon So-min and Yang Se-chan.

Their "second wedding" was aired on Running Man in a special episode called "Big Nose Week" (alluding to Jee's nickname on the show).

[12] They have a son, Jee Hyun-woo, who made a rare appearance on a Running Man episode in 2015.