Jeffersonville is a village in the town of Cambridge, Vermont, United States.

Jeffersonville is 30 miles (48 km) northeast of Burlington via Vermont Route 15.

Jeffersonville sits at 1,060 feet (320 m) above sea level, surrounded by higher standing mountains, such as Mount Mansfield (the highest peak in Vermont at 4,393 feet (1,339 m)), 7 miles (11 km) to the south.

The annual precipitation is significant, averaging 72.3 inches (1,840 mm) and is well-distributed throughout the year, but the latter months are the wettest.

The town's location east of Lake Champlain sometimes accounts for localized snow squalls, producing up to 18 inches (46 cm) in 12 hours on rare occasions.

29.0% of all households were made up of individuals, and 11.7% had someone living alone who was 65 years of age or older.