In 2003 Hubbell joined the faculty at Switzerland's École Polytechnique Fédérale de Lausanne (EPFL) where he served as the founding director of the Institute of Bioengineering.
"[4] In the same year, Hubbell was awarded the Acta Biomaterialia Gold Medal[5] and appointed the inaugural Bell Professor in Tissue Engineering at the University of Chicago.
[15] As to recent research, in 2019[16] and 2023,[17] Hubbell and colleagues, including D. Scott Wilson,[18] published an approach to inverse vaccination, with implications for treatment of autoimmunity.
[20] Following this development, he helped design a new therapy to eventually assist those with autoimmune diseases by fusing a tolerogenic cytokine to a blood protein that accumulates in the lymph nodes.
[21] Effective November 15th, 2024, Hubbell was appointed as professor of chemical and biomolecular engineering in the Tandon School of Engineering with appointments in the Grossman School of Medicine and the Faculty of Arts and Sciences at NYU, leading a cross-institutional initiative with NYU Langone while also serving as Vice President for bioengineering strategy.