Lacker's vote was the solitary dissent in the August, September, October, and December 2006 Federal Open Market Committee (FOMC) meetings.

[4] The FOMC decided to keep interest rates steady at 5.25 percent after a series of seventeen consecutive increases of twenty-five basis points each, while Lacker voted for additional tightening.

At the January 2009 meeting, "Mr. Lacker dissented because he preferred to expand the monetary base by purchasing U.S. Treasury securities rather than through targeted credit programs", according to the FOMC minutes.

In addition Lacker voted against the action at April 2012 meeting: "... who does not anticipate that economic conditions are likely to warrant exceptionally low levels of the federal funds rate through late 2014", according to FOMC press release.

[10] On April 4, 2017, Lacker abruptly resigned his post, admitting that he spoke to a Medley Global Advisors financial analyst about confidential Fed deliberations in 2012, and also "failed to disclose the details of the conversation even when he was questioned directly in an internal investigation.

[12] Lacker is the author of numerous articles in professional journals on monetary, financial, and payment economics, and has presented his work at several universities and central banks.