Buzen was PhD thesis advisor for Robert M. Metcalfe (1973), Turing Award winner and co-inventor of Ethernet, and for John M. McQuillan (1974), developer the original adaptive routing algorithms used in ARPAnet and Internet.

Buzen also co-taught (with Ugo Gagliardi) a two-semester graduate-level course on operating systems (AM 251a/AM251br) that Microsoft co-founder Bill Gates took during his freshman year (1973-74).

The company, which began operations in his basement,[3] developed, marketed and supported software products for the performance management and capacity planning of enterprise computer systems.

This has led the development of an alternative approach to stochastic modeling that makes it possible to derive certain classical results using simpler assumptions that are more likely to be satisfied in practice.

His initial 1976 paper on this topic Fundamental Laws of Computer System Performance received the inaugural ACM Sigmetrics “Test of Time Award” in 2010, reflecting 34 years of enduring influence.