Pullicino Orlando accepted to contest the 2017 general elections with the Labour Party on the insistence of Prime Minister Joseph Muscat.

He was instrumental in the setting up of the Council's research funding programme, 'Fusion', which is considered to be a mainstay of Malta's R and I ecosystem.

The development of Esplora involved the rehabilitation of the former Bighi Naval Hospital, which was in a state of imminent collapse, into a 22,000 square metre complex which includes a unique Planetarium and well over 200 interactive exhibits.

This complicated project, which was partly financed by EU Structural Funding, was completed in two and a half years.

He set it up from scratch, with the full support of his team and central government, to ensure that the Council hit the ground running in what was chosen to be the European Year of Skills.

The Council, which is based in Pembroke, will be focusing on the promotion of specific skills, upskilling and reskilling, to ensure that Malta’s workforce is prepared to make the most out of the employment opportunities arising from a fast-developing economy.

[8] Pullicino Orlando was appointed member of the Board of Governors of the Malta College for Arts, Science and Technology (MCAST) in January 2024.

kENUP's ultimate aim is to ensure that effective and affordable therapeutical agents, ranging from vaccines to pharmaceuticals, are readily available on a global level.

As kENUP Director, Pullicino Orlando was the driving force behind an initiative which saw the Foundation’s offices converted into a residence for 30 Ukrainian refugees in April 2022.

He successfully campaigned against the establishment of a cement plant in the central part of the island which could have had a detrimental impact on his constituents' health, a waste landfill next to the prehistoric temples of Mnajdra and an underground museum which could have potentially damaged St John's Co-Cathedral in Valletta.

His efforts in the environmental field were given formal recognition when he was awarded the title of 'Green Politician of the Year' in 2002 by Nature Trust (Malta).

Militating in favour of such controversial issues in predominantly Catholic Malta has made him the target of conservative journalists and columnists.

He set up the Anti-Cyberharassment Alliance in August 2013, together with a number of prominent individuals such as the former Chairperson of the pro-divorce movement, former Parliamentary Secretary Deborah Schembri, and former minister Jesmond Mugliett.

It is considered to give a valuable perspective of the events that shaped recent Maltese history, given that – quite uniquely - the author has been directly involved with both major parties at the highest of levels.