[1] Bolles became interested in osteopathy based upon the treatment her family received by Dr. Andrew Still.
[1] There is a profession… which is peculiarly adapted to women, which is fascinating, satisfactory, and directly beneficial to mankind… it is Osteopathy.
[3] The school, a charter member of the Associated Colleges of Osteopathy, maintained a course of four-five month terms.
[3] She was offered the appointment to the State Medical Board by Governor John F. Shafroth, but she turned it down because they did not recognize osteopathy.
She received the AOA Distinguished Service Certificate for "Pioneering in Osteopathy as a Profession for Women" in 1925.
Bolles helped found the Osteopathic Women's National Association and served as president three times.
[3] She married Newton A. Bolles in 1887,[1][2] who was also a graduate of the School of Osteopathy and received his degree in 1898.
[1][2] Bolles was an active member of the Mother's Congress, now called the Parent Teachers Association, and served on the Child Hygiene Committee.
She served as the representative for Colorado at the final International Congress of Child Welfare in Washington, D.C. She was a suffragette, Congregationalist, and a Republican.