Yuh spent her childhood in Lakewood, California, where she enjoyed watching martial arts movies, playing with cars, and drawing.

[4] Following a brief stint at Hanna-Barbera Productions on The Real Adventures of Jonny Quest for Cartoon Network,[7] she was later hired as a storyboard artist on HBO's Todd McFarlane's Spawn series in 1997.

[8] In 1998, Yuh joined DreamWorks Animation as a storyboard artist, where she worked on Spirit: Stallion of the Cimarron, Sinbad: Legend of the Seven Seas, and Madagascar.

As a big fan of martial arts movies, she asked to work on the first Kung Fu Panda film, where she served as head of story and director of the opening hand-drawn dream sequence.

[12] In 2016, Yuh announced that she would be making her live action directorial debut with an adaptation of Alexandra Bracken's The Darkest Minds for 20th Century Fox.

She described herself as soft-spoken, contrary to what contemporary directors are often personified as; instead, she used storyboards to help pitch her ideas to Shawn Levy and 21 Laps.

[14] In June 2019, Yuh was hired as supervising director of the second season of the Netflix animated anthology series, Love, Death & Robots.