[5][6] As an associate professor of statistics at the University of British Columbia,[7] Bryan worked on biostatistics with a focus on gene expression and microarray data.
Notable projects to which she has contributed include the quantification of photomotor responses in larval zebrafish,[8] the development of an assay system in the multicellular animal Caenorhabditis elegans to test genetic interactions causing synthetic lethality in somatic cells,[9] and a novel yeast-based model to search for modifier genes involved in cystic fibrosis.
[11] Her general science contributions include a manifesto published in PLOS One on good practices for scientific computing[12] and an introduction to the Git version control system[13] for research data analysis.
[14][15][16] Bryan's teaching activities at UBC included development of the Master of Data Science Program[17] and new materials for the STAT 545 course.
[15] As of late 2016 Bryan is on leave from her UBC position and is working at RStudio with a team led by Hadley Wickham.