Rain began her career with starring roles in several local stage productions in Charleston before moving to New York City in the early 1970s.

Outside of film, Rain had a supporting role as Nurse Samantha Tolliver in the soap opera The Doctors (1972–77), followed by guest appearances on several soap operas, including General Hospital, and starring roles in off-Broadway productions, including 22 Years and The Fan Club.

At the age of 28, Rain was diagnosed with systemic lupus and has launched several philanthropic efforts to bring awareness to the disease.

[5] Rain played Nurse Samantha Tolliver in the soap opera The Doctors from 1972 to 1977 and had guest appearances on General Hospital.

[6] In 2000, David A. Szulkin interviewed Rain for his book Wes Craven's Last House on the Left, which tells the inside story of making the film.