Evarts was influenced by the effects of the Second Great Awakening and served the American Board of Commissioners for Foreign Missions as its treasurer from 1812 to 1820 and Secretary from 1821 until he died in 1831.

Evarts was the editor of The Panoplist, a religious monthly magazine from 1805 until 1820,[clarification needed] where he published over 200 essays.

[1] In 1830, Georgia passed a law which prohibited whites from living on Indian territory after March 31, 1831, without a license from the state.

These missionaries were trying to help the Indians resist removal through efforts to integrate them into the white society through conversion and education.

He died of tuberculosis on May 10, 1831, in Charleston, South Carolina, having overworked himself in the campaign against the Indian Removal Act.