He played college football for the Notre Dame Fighting Irish, where he won the Butkus Award and was named the ACC Defensive Player of the Year and a unanimous All-American as a senior in 2020.

[2] Owusu-Koramoah was rated a three-star recruit and initially committed to play college football at the University of Virginia in 2016 before decommitting to choose Notre Dame.

[8] He won the Butkus Award as the nation's top linebacker as a senior in 2020, in addition to being named a unanimous All-American and the ACC Defensive Player of the Year.

[15][16] Koramoah recorded his first career sack on Chicago Bears quarterback Justin Fields in Week 3 of the 2021 season.

[21] His older brother, Joshua Emmanuel Owusu-Koramoah, was found dead inside a burned house on April 5, 2022.