Newsome attended Glenbard North High School in Carol Stream, Illinois before transferring to IMG Academy in Bradenton, Florida for his senior year.

[15] On September 12, 2021, Newsome started in his professional regular season debut and had one solo tackle during a 29–32 loss at the Kansas City Chiefs.

On December 10, 2021, Newsome suffered a concussion after hitting his head during the last play of a practice and was subsequently sidelined for three games (Weeks 14–16).

[17] Kn January 3, 2022, he racked up a season-high eight combined tackles (seven solo) and deflected two passes as the Browns lost 14–26 at the Pittsburgh Steelers.

In the 2022 NFL season, Newsome recorded a total of 42 combined tackles (31 solo), six pass deflections, and was credited with half a sack in 15 games and 15 starts.

[22] On January 18, 2023, the Cleveland Browns hired Jim Schwartz as the new defensive coordinator after firing Joe Woods the week prior.