He also earned first-team All-Colorado and all-conference honors as a junior, helping his team reach the state quarterfinals.

As a sophomore, Sirles helped Bear Creek reach the state quarterfinals, garnering first-team All-South Metro League and second-team all-state honors.

[4] Sirles made his NFL debut on December 20, 2014, against the San Francisco 49ers filling in as guard for an injured Johnnie Troutman.

[8] In the 22–10 upset at Carolina in Week 3 of the 2016 season, Sirles played the final 39 minutes at left guard when Alex Boone went down because of a hip injury.

The following week, Sirles stepped in at right tackle after Andre Smith went down with an elbow injury with eight minutes left in the first quarter.

On March 23, 2018, Sirles signed a one-year contract with the Carolina Panthers, reuniting with former Vikings offensive coordinator Norv Turner.